Mild Traumatic Brain Injury Apparatus – mTBI
Kuwait University - College of Medicine
We were nominated by Dr. Yadikar and Ms. Merva from the College of Medicine at Kuwait University to work on a project aimed at inventing a new device for inducing mild traumatic brain injuries in mice. The primary objective was to design a device capable of delivering precise impulse hits to a focal point without fracturing the skull, unlike conventional devices that rely on direct weight impact.
To achieve this, we designed all components in a modular, LEGO-style format to facilitate research and development stages. Over four versions of the device were created, leading to the finalized version illustrated above. The system comprises two key mechanisms:
Impulse Mechanism: When the weight is released, it activates a mechanical system that delivers an impulse hit without causing skull fractures or multiple impacts. This mechanism was validated through engineering simulations, including multiphysics motion analysis conducted in SolidWorks.
Clamp Mechanism: A frictionless weight holder ensures the weight is released in a controlled, single-click action. Multiple versions were developed and tested to accommodate ten different weights.
Additionally, the design includes a customized restraint mechanism tailored to the anatomical profiles of mice of various sizes, effectively limiting movement during the procedure. The device also features modular tubes designed in a LEGO-style format, allowing users to easily adjust the height to achieve different impact forces. This modular design ensures flexibility and ease of use while maintaining secure connections for consistent results.
This innovative approach aims to enhance research accuracy and safety, advancing methods for studying mild traumatic brain injuries in animal models.